Lilly Postdoctoral Scientist-Mass Spectrometry in Indianapolis, Indiana
At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.
The primary responsibility of this candidate is to develop and apply cutting-edge mass spectrometry methodologies to characterize oligonucleotides (e.g., siRNAs), proteins and new therapeutic modalities, such as gene and cell therapies. The candidate will join a state-of-the-art structural characterization group in Bioproduct Research & Development where he/she will apply broad scientific knowledge and laboratory skills to provide LC-MS support for drug development activities at all stages and across diverse platform pipeline (e.g., RNA/DNA, peptides, proteins and other modalities).
Responsibilities/Tasks include but not limited to:
Evaluate, develop and apply LC-MS methods for detailed structural characterization of RNA/DNA, proteins, and other new therapeutic modalities such as gene and cell therapies, as well as their impurities.
Identify and monitor new technologies and trends for the analysis and characterization of oligonucleotides, proteins, and other new therapeutic modalities. Deliver innovative solutions to solve challenging characterization problems for novel therapeutics.
Participation in cross-functional teams and effective collaboration with other areas in development including process, formulation, and analytical development, as well as discovery and manufacturing.
Present findings at conferences and publish in high quality peer-review journals.
Ph.D. in Chemistry, Biochemistry or related field.
Expertise in oligonucleotide or/and protein structural characterization using mass spectrometry.
Thorough understanding of modern MS structural characterization techniques and methodology.
Extensive experience with high-resolution MS instruments (e.g., Q-TOF, Orbitrap).
Experience with LC-MS data analysis platforms (e.g., BioPharma Finder, Protein Metrics, MassLynx, XCalibur, MassHunter). Familiarity with programming is desirable.
In-depth knowledge of oligonucleotide design and synthesis is a plus.
Experience in application of MS for gene and cell therapies is a plus.
High learning agility by identifying and exploiting new scientific concepts, strong technical problem-solving skills, and self-motivated to achieve quality results in a fast-paced environment.
Effective oral and written communication skills. Ability to work both independently and in an interdisciplinary team environment.
Additional Information :
- It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete.
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