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Lilly Postdoctoral Scientist-Mass Spectrometry in Indianapolis, Indiana

At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

Organization Overview:

The primary responsibility of this candidate is to develop and apply cutting-edge mass spectrometry methodologies to characterize oligonucleotides (e.g., siRNAs), proteins and new therapeutic modalities, such as gene and cell therapies. The candidate will join a state-of-the-art structural characterization group in Bioproduct Research & Development where he/she will apply broad scientific knowledge and laboratory skills to provide LC-MS support for drug development activities at all stages and across diverse platform pipeline (e.g., RNA/DNA, peptides, proteins and other modalities).

Responsibilities/Tasks include but not limited to:

  • Evaluate, develop and apply LC-MS methods for detailed structural characterization of RNA/DNA, proteins, and other new therapeutic modalities such as gene and cell therapies, as well as their impurities.

  • Identify and monitor new technologies and trends for the analysis and characterization of oligonucleotides, proteins, and other new therapeutic modalities. Deliver innovative solutions to solve challenging characterization problems for novel therapeutics.

  • Participation in cross-functional teams and effective collaboration with other areas in development including process, formulation, and analytical development, as well as discovery and manufacturing.

  • Present findings at conferences and publish in high quality peer-review journals.

Basic Qualifications

  • Ph.D. in Chemistry, Biochemistry or related field.

  • Expertise in oligonucleotide or/and protein structural characterization using mass spectrometry.

Additional Skills/Preferences

  • Thorough understanding of modern MS structural characterization techniques and methodology.

  • Extensive experience with high-resolution MS instruments (e.g., Q-TOF, Orbitrap).

  • Experience with LC-MS data analysis platforms (e.g., BioPharma Finder, Protein Metrics, MassLynx, XCalibur, MassHunter). Familiarity with programming is desirable.

  • In-depth knowledge of oligonucleotide design and synthesis is a plus.

  • Experience in application of MS for gene and cell therapies is a plus.

  • High learning agility by identifying and exploiting new scientific concepts, strong technical problem-solving skills, and self-motivated to achieve quality results in a fast-paced environment.

  • Effective oral and written communication skills. Ability to work both independently and in an interdisciplinary team environment.

Additional Information :

  • It is for a fixed duration of two years with potential to extend to 3 years and for maximum of up to 4 years. You will have opportunities to apply for full time positions after your duration is complete.

Eli Lilly and Company, Lilly USA, LLC and our wholly owned subsidiaries (collectively “Lilly”) are committed to help individuals with disabilities to participate in the workforce and ensure equal opportunity to compete for jobs. If you require an accommodation to submit a resume for positions at Lilly, please email Lilly Human Resources ( ) for further assistance. Please note This email address is intended for use only to request an accommodation as part of the application process. Any other correspondence will not receive a response.

Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

At Lilly we strive to ensure our employees are part of a team that cares about them and our shared purpose of making life better for those around the world. How do we do this? We continue to look for ways to include, innovate, accelerate and deliver while maintaining integrity, excellence and respect for people.​ We hope that you seek to join us on our journey as we create medicine and deliver improved outcomes for patients across the globe!